The contribution of Stalosan F toward decreased pre-weaning mortality and diarrhea


The vigorous genetic selection for increased litter size has raised pig production to a higher level. The greater number of piglets reduces the cost per housed sow, increasing the system’s profitability. However, prolificacy is also associated with higher pre-weaning mortality rates, one of the most significant challenges for swine producers. As large litters provide substantial challenges for sows and litter management, new technologies are required to reduce pre-weaning mortality.


Pre-weaning mortality

Pre-weaning mortality represents a cost to the swine producer: it is a lost opportunity to profit and is considered a significant economic loss and welfare concern in commercial pig production. Pre-weaning mortality might range between 10% and 20% in pig-producing countries (Muns et al., 2016).

The birth is arguably the most critical event in the piglet’s life. The neonate must cope with a harsh cold environment where they must “learn” pulmonary breathing and compete for food. Indeed, 50–80% of piglet deaths occur during the first week after birth, with the most critical period being the first 72 hours of life (Koketsu et al., 2006). In addition, piglets are also born physiologically and immunologically immature, making them reliant on proper management and optimal sanitary conditions.



Diseases that affect the suckling piglet are well known to swine producers, especially those that cause diarrhea. Neonatal diarrhea increases morbidity and mortality, resulting in increased pre-weaning mortality, poor growth rates, and variations in weight at weaning.

Diarrhea occurrences result from several factors, including infectious agents, host immunity, and management procedures (Wittum et al., 1995). When the infection pressure is excessively high or when the immune activity of the suckling piglet is impaired, the risk of outbreaks is considerably higher. Therefore, among the most critical managements for control and prevention of diarrhea in suckling piglets are sows’ vaccination before farrowing, proper stimulation of colostrum intake, adequate environmental temperature for sows and piglets, prevention of heat loss by piglets immediately after birth, and elevated environmental sanitation (Shankar et al., 2009).


Prevention and control of diarrhea using Stalosan F

Any discussion on farrowing room management begins with sanitation and the excellent hygiene of the environment, as most of the infectious agents that cause diarrhea may arise from environmental contamination. In this context, Stalosan F plays a vital role in a farm’s sanitation program. It can be used after disinfection before sow entry to the farrowing house and during the lactation period to prevent bacterial growth and minimize disease challenges.

When applied once a week, Stalosan F maintains a dry environment, reducing the incidence and severity of neonatal diarrhea. In addition, Stalosan F may reduce pre-weaning mortality and increase the performance of piglets during the suckling period. Moreover, Stalosan F can reduce diarrhea in piglets by over 50%, which leads to fewer antibiotic treatments.

Furthermore, Stalosan F provides quick and effective drying when used directly on newborn piglets, protecting them from excessive heat loss that may lead to diarrhea or even death.



It’s nothing new that piglet mortality and diarrhea demand effective strategies to mitigate their effects in commercial facilities. Those strategies involve a multifactorial approach and must be conducted, considering each farm’s particular circumstances. However, in all cases, Stalosan F is a decisive contribution to maintaining high environmental sanitation standards and proper early care in farrowing rooms.



Koketsu, Y., Takenobu, S., Nakamura, R. Preweaning mortality risks and re- corded causes of death associated with production factors in swine breeding in Japan. Journal of Veterinary Medicine Science, v. 68, p. 821–826, 2006.

Muns, R., Nuntapaitoon, M., Tummaruk, P. Non-infectious causes of pre-weaning mortality in piglets. Livestock Science, v. 184, p. 46–57, 2016.

Shankar, B. P., Madhusudhan, H. S., Harish. D. B. Pre-weaning mortality in pig causes and management. Veterinary World, v. 2, p. 234-236.

Wittum T.E., Dewey C.E., Hurd H.S., Dargatz D.A., Hill G.W. Herd and litter-level factors associated with the incidence of diarrhea morbidity and mortality in piglets 1-3 days of age. Journal of Swine Health and Production, v. 3, p. 99-104, 1995.

Learn how ammonia emissions negatively impact pig performance and how to mitigate them


The most common complaint producers hear when people drive past or visit a pig barn is the smell. Ammonia, a gas released when manure decomposes, can be easily recognized by its pungent odor. Ammonia can be detrimental to the health and welfare of animals and employees, even at low concentrations. Livestock production is responsible for almost 64% (Dopelt et al., 2019) of global ammonia emissions. The global swine industry is responsible for about 15% of ammonia emissions associated with livestock. The swine industry’s contribution varies by region due to the concentration of animals and can be as high as 60% in areas of China and 25% in Europe (Oliver et al., 1998; Philippe et al., 2011; Xu et al., 2014).

Considering that scenario, many swine producers must ask: how can we control ammonia in grow-finish operations? First, it’s necessary to understand where ammonia originates. In swine operations, ammonia is a byproduct of microbial decomposition of urine and feces in the manure storage pit below the floor.

A simple explanation for this complex process is:

  • Urea, from urine, is converted to ammonia and carbon dioxide by the microbial enzyme urease (from microbes excreted in feces).

  • Once formed, free ammonia can take two forms, depending on the pH of the manure: NH3 (ammonia) or the ammonium ion (NH4+).

  • At low pH, most of the ammonia remains in the liquid as NH4+.

  • At pH greater than 7, the ammonium ion is converted to ammonia (NH3) and can escape as gas.


Strategies to control ammonia production

Ammonia volatilization is a process that depends on many factors such as relative humidity, animal density and activity, amount of manure and urine on the floor, airspeed in the building, and dry matter content in the manure (Blanes-Vidal et al., 2008; Fabbri et al., 2007). Throughout all stages of pig production, ammonia production is a concern, but most specifically in grow-finish operations, which account for 60–70% of the total nitrogen excretion (Jongbloed and Lenis, 1993). Considering the above, efforts to reduce ammonia production are necessary.

Environmental and nutritional management practices are necessary to reduce ammonia levels in pig production significantly. Environment control, especially ventilation, is one strategy to reduce ammonia emissions. According to Tabase et al. (2018), managing the NH3 emission from livestock buildings requires introducing fresh air into the units while avoiding over-ventilation above the manure-covered surfaces. Another way of introducing fresh air is to adjust inlet openings, promoting constant airflow into the buildings. Biofilters and scrubbers can also be used in mechanically ventilated systems, as they encourage air purification.

Manure management is also crucial when it comes to reducing ammonia emissions. Removal of manure is recommended 1-2 times per day from pig stalls. Storing manure for an extended period increases ammonia production within the facility. For example, a storage period of 3 days can result in a 40% increase in NH3 (Botermans et al., 2010). Therefore, under ideal circumstances emptying the pit frequently is advised. Additionally, methods for reducing microbial activity in manure may be helpful, such as using additives to lower the pH.

Pen design and hygiene are also essential factors to consider. Cleaning the slats and the lying area should be the primary objective. Botermans et al. (2010) suggested a slope with an incline between 2% and 3% on the floor to help drain urine. Furthermore, the excretion area should account for at least 25% of the lying area. Keeping pigs clean and dry is also critical, especially in the summer, when heat-stressed animals change their behavior and start lying on the slatted floor.

Dietary manipulation can also aid in the control of ammonia emission by minimizing the crude protein level within the diet. Le et al. (2009) demonstrated that reducing crude protein in pig diets can significantly reduce ammonia emission from manure. Portejoie et al. (2014) reported that dietary protein reduction from 20% to 12% resulted in a 63% reduction of ammonia emissions.



How does ammonia affect grow-finish operations without proper control?

The negative impact of ammonia emissions goes far beyond its irritating odor. High concentrations of ammonia are detrimental to the health of both pigs and the people working in the facilities. Ammonia levels of 7 ppm can reduce pulmonary function in swine farm workers (Donham et al., 1989; Donham et al., 1995), and concentrations above 35 ppm promoted inflammatory changes in the wall of the respiratory tract and reduced bacterial clearance from lungs in young pigs (Drummond et al., 1978). High levels of ammonia within the barn can also cause an increase in pig restless, and ear, tail, and flank biting. In addition, ammonia concentrations of 50 ppm or above can cause inflammation of the respiratory tract, increasing susceptibility to respiratory infections by reducing the rate of bacterial clearance (Gustin et al., 1994; Urbain et al., 1994). High levels also affect animal performance, reducing growth rates up to 12% during prolonged periods of exposure (Drummond et al., 1980).



Ammonia emission is a constant challenge for all swine producers since high concentrations of this gas have harmful effects on pig health and performance. This article has provided an overview of ammonia volatilization, how grow-finish pigs are affected, and practical strategies for reducing its concentration in swine buildings. If a single ammonia mitigation method doesn’t work, farms should consider using several approaches to control ammonia in grow-finishing operations.

Find more information at for ammonia mitigation solutions, including Stalosan F: a valuable tool when it comes to ammonia control. Stalosan F acts as a buffer that chemically controls manure moisture and pH. Furthermore, Stalosan F inhibits urease enzyme activity, decreasing the conversion of urea to ammonia.



Blanes-Vidal, V., Hansen, M. N., Pedersen, S., & Rom, H. B. (2008). Emissions of ammonia, methane and nitrous oxide from pig houses and slurry: Effects of rooting material, animal activity and ventilation flow. Agriculture, Ecosystems & Environment, 124(3-4), 237-244. DOI:

Botermans, J., Gustafsson, G., Jeppsson, K. H., Brown, N., & Rodhe, L. (2010). Measures to reduce ammonia emissions in pig production (No. 2010: 1).

Donham, K., Haglind, P., Peterson, Y., Rylander, R., & Belin, L. (1989). Environmental and health studies of farm workers in Swedish swine confinement buildings. Occupational and Environmental Medicine, 46(1), 31-37.

Donham, K. J., Reynolds, S. J., Whitten, P., Merchant, J. A., Burmeister, L., & Popendorf, W. J. (1995). Respiratory dysfunction in swine production facility workers: Dose‐response relationships of environmental exposures and pulmonary function. American journal of industrial medicine, 27(3), 405-418. DOI: 10.1002/ajim.4700270309

Dopelt, K., Radon, P., & Davidovitch, N. (2019). Environmental effects of the livestock industry: the relationship between knowledge, attitudes, and behavior among students in Israel. International journal of environmental research and public health, 16(8), 1359. DOI:

Drummond, J. G., Curtis, S. E., Simon, J., & Norton, H. W. (1980). Effects of aerial ammonia on growth and health of young pigs. Journal of Animal Science, 50(6), 1085-1091.

Drummond, J. G., Curtis, S. E., & Simon, J. (1978). Effects of atmospheric ammonia on pulmonary bacterial clearance in the young pig. American journal of veterinary research, 39(2), 211-212.

Fabbri, C., Valli, L., Guarino, M., Costa, A., & Mazzotta, V. (2007). Ammonia, methane, nitrous oxide, and particulate matter emissions from two different buildings for laying hens. Biosystems Engineering, 97(4), 441-455. DOI: 10.1016/j.biosystemseng.2007.03.036

Gustin, P., Urbain, B. R. U. N. O., Prouvost, J. F., & Ansay, M. (1994). Effects of atmospheric ammonia on pulmonary hemodynamics and vascular permeability in pigs: interaction with endotoxins. Toxicology and applied pharmacology, 125(1), 17-26. DOI: 10.1006/taap.1994.1044

Jongbloed, A. W. and N. P. Lenis (1993). Excretion of nitrogen and some minerals by livestock. In: M.W.A. Verstegen, L. A. Den Hartog, G.J.M. van Kempen, and J.H.M. Metz (Eds.). Nitrogen Flow in Pig Production and Environmental Consequences. EAAP Publ. Pudoc, Wageningen, The Netherlands. 69: 22- 36.

Le, P. D., Aarnink, A. J. A., & Jongbloed, A. W. (2009). Odor and ammonia emission from pig manure as affected by dietary crude protein level. Livestock Science, 121(2-3), 267-274. DOI:

Olivier, J. G. J., Bouwman, A. F., Van der Hoek, K. W., & Berdowski, J. J. M. (1998). Global air emission inventories for anthropogenic sources of NOx, NH3, and N2O in 1990. Environmental Pollution, 102(1), 135-148. DOI:

Philippe, F. X., Cabaraux, J. F., & Nicks, B. (2011). Ammonia emissions from pig houses: Influencing factors and mitigation techniques. Agriculture, ecosystems & environment, 141(3-4), 245-260. DOI:

Portejoie, S., Dourmad, J. Y., Martinez, J., & Lebreton, Y. (2004). Effect of lowering dietary crude protein on nitrogen excretion, manure composition, and ammonia emission from fattening pigs. Livestock Production Science, 91(1-2), 45-55. DOI:

Tabase, R. K., Millet, S., Brusselman, E., Ampe, B., Sonck, B., & Demeyer, P. (2018). Effect of ventilation settings on ammonia emission in an experimental pig house equipped with artificial pigs. Biosystems Engineering, 176, 125-139. DOI:

Urbain, B., Gustin, P., Prouvost, J. F., & Ansay, M. (1994). Quantitative assessment of aerial ammonia toxicity to the nasal mucosa by use of the nasal lavage method in pigs. American Journal of Veterinary Research, 55(9), 1335-1340.

Xu, W., Zheng, K., Liu, X., Meng, L., Huaitalla, R. M., Shen, J., … & Zhang, F. (2014). Atmospheric NH3 dynamics at a typical pig farm in China and their implications. Atmospheric Pollution Research, 5(3), 455-463. DOI:

The health status of swineherds has significant implications on animal welfare and production efficiency, including growth rate, feed conversion, and profitability. Therefore, swine producers and veterinarians work daily to improve and maintain the health of their herds through critical biosecurity practices. There are many definitions of biosecurity. Simply put, biosecurity is practices implemented to prevent the introduction or prevent the further spread of pathogens capable of causing disease.



The classic form of biosecurity is bioexclusion – practices put into place to prevent the introduction of pathogens into a farm or population of animals from an outside source. Standard bioexclusion methods include downtime for personnel entering the facility, cross-over entry benches, and shower-in shower-out procedures. Another concept of biosecurity often overlooked is biocontainment. Biocontainment is the concept of keeping pathogens from spreading off a farm and to other facilities or even preventing spread within groups of animals within a single farm. Both bioexclusion and biocontainment are necessary to consider when developing a biosecurity program.

A successful biosecurity program has several key components. First and foremost, for any plan to be successful, the organization must embrace a culture of biosecurity which includes consistent expectations and accountability at all levels of the organization. If an organization lacks an appropriate biosecurity culture, it is difficult to consistently implement the plan as a whole, which can lead to an undesirable level of success.

A second key component of biosecurity is the training of employees with a specific focus on WHY the procedures are essential and HOW those practices can maintain the high herd health of the animals they are involved in raising. Furthermore, biosecurity generally requires additional time, effort, and expense compared to no biosecurity measures. Thus, resources and protocols are necessary to simplify the biosecurity process. Proper infrastructure is also vital for employees to implement any biosecurity program. Features that help employees perform the daily tasks in a more biosecure way dramatically increase the success of these practices. The final component of a biosecurity program is continuous improvement and resources, such as routine audits and diagnostic testing. These programs can help identify potential inconsistencies within a biosecurity program before there is a problem.

Biosecurity advances in the swine industry have been abundant in recent decades, greatly expanding our knowledge of infectious disease transmissions such as PRRSV, PEDV, and other common diseases. By pinpointing the most common risks of disease transmission, swine producers have put practices into place to further improve against infectious diseases. One of the most common risks emphasized in biosecurity research is the movement of people, animals, and fomites within the swine production system (Gebhardt et al., 2021; Greiner, 2016). Several practices have helped control these biosecurity risks, such as limiting farm visitors, using farm sign-in books, documenting animal movements, and on-farm sanitation. Most farms also are supplied with facility-only clothing and tools necessary for daily tasks, minimizing cross-contamination from outside the farm. In addition, equipment like autoclaves and sterilizers are becoming more common at farm entrances to reduce the risk of pathogen entry through supplies and equipment brought onto the farm. Air filtration units are also being installed on most swine farms, minimizing the risk of virus introduction through aerosol particles.

Production facilities with multiple locations and ones that practice an all-in-all-out approach are also essential to reducing prevalences of growth-suppressing diseases. Multi-site production systems are standard in commercial swine production, where breeding, gestation, and farrowing are separate from the other production phases. Separating the different stages of production minimizes newborn piglets’ exposure to infectious agents that may decrease their growth performance down the line. These facilities also usually follow an all-in-all-out protocol when moving animals between farms or rooms. By transporting pigs of similar age, weight, and production stage, farmers can further reduce disease transmission, improve management, and provide better environmental control. With these advances, knowledge is available regarding best practices for farm implementation (Levis and Baker, 2011; FAO, 2010).

While many of these concepts are relatively intuitive and have been around for some time, consistent implementation remains a challenge, and we continue to face difficulties to swine health daily. Biosecurity is always ongoing and contains a series of hurdles; there is no silver bullet. However, organizations can continue developing and refining their programs by focusing on the four fundamental concepts of swine biosecurity. The four concepts: 1) culture, 2) training, 3) infrastructure, and 4) continuous improvement are critical components of a successful biosecurity program in swine production.




Food and Agriculture Organization of the United Nations/World Organisation for Animal Health/World Bank. 2010. Good practices for biosecurity in the pig sector – Issues and options in developing and transition countries. FAO Animal Production and Health Paper No. 169. Rome, FAO.


Gebhardt, J.T., S.S. Dritz, C.G. Elijah, C.K. Jones, C.B. Paulk, and J.C. Woodworth. 2021. Sampling and detection of African swine fever virus within a feed manufacturing and swine production system. Transbound. Emerg. Dis. doi:10.1111/tbed.14335.


Greiner, L.L. Evaluation of the likelihood of detection of porcine epidemic diarrhea virus or porcine delta coronavirus ribonucleic acid in areas within feed mills. J Swine Health Prod. 2016. 24(4):198–204.


Levis, D.G., and R.B. Baker. 2011. Biosecurity of pigs and farm security. University of Nebraska, Lincoln.